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Mera System and Bioconsumable Plate
Mera System and Bioconsumable Plate

Mera System

Overview

Hooke Bio’s Mera has the ability to culture, drug and stain MPS’s at higher throughput than existing technologies while analysing physiological metrics relevant to drug functionality and toxicity in real time through a fully automated integrated fluorescent microscope.

To benchmark Mera against existing 3D culture systems, HepG2 spheroids were cultured on the bioconsumable plate in Mera and compared to spheroids grown on a microplate in an incubator. The spheroids were stained with Calcein AM (response shown in green indicating good viability) and EthD-1 (response shown in red indicating low levels of apoptosis). In addition to viability, the recirculation fluidics can support inter spheroid signalling mimicking the fluidic systems in the human body.

In house image analysis software was developed to facilitate reproducible measurement of physiological Responses in MPS’s. Data generated on the Mera system demonstrate that HepG2 spheroids exposed to APAP give similar levels of cell death in comparison to spheroids cultured in microplates also exposed to APAP.

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FEATURES
  • Fully automated integrated system
  • Precise feeding and dosing flow control
  • Microphysiological system (MPS)
  • Communication via fluidic interactions
  • On system imaging
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Currently only 1 in 10 drugs make it through clinical trials to market due mostly to poor preclinical models. Based on recent literature, 3D microtissues which are also known as organoids/spheroids, give more physiological responses than 2D models and may be suitable replacement for animal models.

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Bioconsumable plate

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OVERVIEW

The Hooke Bio system comes in two parts, a Bioconsumable plate and the Mera platform. Our system has the ability to feed, wash, drug, and/or stain microtissues within the bioconsumable plate and has the ability to maintain and treat up to 800 microtissues simultaneously.

Mera supports fluidic recirculation. mimicking conditions within the human body and its integrated optics to allow for live microtissues metric assessment.

FEATURES
  • In vivo type environment
  • Parallel culture of different microtissue
  • Inter-tissue interaction
  • SBS/ANSI format