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Mera System

Overview

Hooke Bio’s Mera has the ability to culture, drug and stain 3D microtissues at higher throughput than existing technologies while analysing physiological metrics relevant to drug functionality and toxicity in real time through a fully automated integrated fluorescent microscope.

Benchmarking Mera Against Traditional 3D Culture Systems
Mera sets a new standard in 3D cell culture. To highlight its versatility and performance, a variety of microtissues and spheroids have been cultured on Mera and compared to those grown in conventional microplates within standard incubators. Unlike traditional platforms, Mera is cell-agnostic—designed to support any cell type with ease.

Using our integrated fluorescence imaging system, microtissues are stained directly within Mera using Calcein AM (green, indicating high viability) and EthD-1 (red, indicating apoptosis), enabling real-time viability assessments without manual intervention. But Mera goes beyond viability. Its advanced recirculating fluidics promote inter-microtissue communication, simulating the dynamic flow and signaling found in the human body—bringing in vitro systems closer to in vivo conditions than ever before.

Precision Analytics, Proven Results
Mera’s custom-built image analysis software enables consistent, reproducible measurement of physiological responses in 3D microtissues. Toxicity testing on the system shows that drug-induced cell death closely mirrors results from traditional microplate cultures—but with a crucial advantage: Mera’s fluidic environment more accurately replicates human physiological conditions, delivering data with greater translational relevance.